BCG INFECTION IN IMMUNOCOMPROMISED PERSONS.
Beata Wolska – Kuśnierz, Ewa Bernatowska,1 Małgorzata Pac, Barbara Pietrucha, Magdalena Kurenko – Deptuch, Edyta Heropolitańska - Pliszka, Zofia Zwolska
Department of Immunology, Children’s Memorial Health Institute, Warsaw, Poland Department of Microbiology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
Severe adverse events following BCG vaccination
are very rare , but cases of disseminated disease are noted in patients
with congenital or aquired immunodeficiencies. In group of seven hundred
four patients with primary immunodeficiencies registered in Department of
Immunology, Children’s Memorial Health Institute in Warsaw between 1980
– 2003 severe adverse events after BCGvaccination were estimated. The
most frequent was group of antibody deficiencies recognised in 399 cases.
Tcell or combined immunodeficiencies were diagnosed in 187 patients. Among
this group we noted 19 children with severe combined immunodeficiencies, 3
cases of Omenn’s syndrome, 10 children with Di George’a anomaly. Group
of phagocytic disorders consists of 77 patients. Deficiencies of IFN –.
receptor was recognised in 4 children , we noticed one case of IL- 12
recepto r deficiency. In the group of 33 patients with other deficiencies
hyper IgE syndrome was the most frequent.